Presenilin: RIP and beyond

Arie Rip

Intramembrane proteolysis by presenilin and presenilin-like proteases.

Regulated intramembrane proteolysis is a novel mechanism involving proteases that hydrolyze their substrates in a hydrophobic environment. Presenilin (PS) 1 and PS 2 are required for intramembrane cleavage of an increasing number of type I membrane proteins, including the amyloid precursor protein of Alzheimer's disease and the Notch receptor, which signals during differentiation and developmen...

Don't Rip and Replace, Integrate!

Since the inception of OO approaches to developing applications, the focus has been on applying these techniques to build applications that replace older and more inflexible applications – essentially, the rip and replace approach. However, over the same time period, technology has accelerated the pace of change and enabled new ways of doing business. Companies are being forced to understand an...

Rip Currents

Scientific T To examine the spatial and temporal variability of rip currents using remote video imaging techniques. T To quantify changes in nearshore circulation and topography in response to varying incident wave conditions at different time scales including; P wave groupiness (time scales of 1-10 minutes), P tidal modulation (time scales of 12h and 24 h) and P wave height fluctuations associ...

Rip Channels and Nearshore Circulation

Results from an experimental investigation into the e ects of rip channels on the nearshore circulation system are presented The results show that periodic channels in an otherwise longshore uniform bar induce longshore pressure gradi ents that drive pairs of counter rotating circulation cells Dense measurements of wave height wave setup and induced currents are presented In addition ev idence ...